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The class of GABAergic nootropics include any compounds which interact with GABAergic neurons in the brain. GABA is a neurotransmitter that has a naturally inhibitory effect on stress responses in the central nervous system. GABA (Gamma-Aminobutyric Acid) works to eradicate the over-firing of nerves, thus neutralizing stress and anxiety reactions before they happen. It does this by binding with receptor sites before they can be activated by stress-induced neurotransmitters.

GABAergics have a calming, anxiolytic effect. They are known to promote feelings of balanced emotion and tranquility in users. They are also widely used to promote rest and proper sleep cycles, especially for people who experience insomnia.