Centrophenoxine is to DMAE like Alpha-GPC is to Choline-Bitartrate, an option that is better absorbed since the active molecule is bound to an absorption enhancer. Centrophenoxine carries the benefits of DMAE, and may boost Cognition in the elderly.
Centrophenoxine is a Cholinergic compound with a DMAE (Dimethylaminoethanol) component, and acts as a better absorbed transporter of DMAE into the brain.
It is sold under the brand name Lucidril but can easily be bought over the counter or online.It is effective in reversing some of the signs of aging (particularly waste product buildup in the brain) when taken for an acute period (high doses for a month) and can act as a general neural enhancer and protector when taken continuously at a lower dose.
Centrophenoxine (Meclofenoxate) is one of the original Nootropics. And it’s backed by 50 years of research.
Centrophenoxine is sold as the prescription medication Lucidril® in some parts of the world. In other countries like the USA it’s sold as an OTC supplement.
Centrophenoxine is an ester (chemically-derived) compound of DMAE and pCPA. DMAE is a Choline source that acts as a precursor to acetylcholine in your brain. And pCPA is a synthesized version of a plant growth hormone.
This combination helps cross the blood-brain barrier more easily than just supplementing with DMAE.
Centrophenoxine is a great addition to any nootropic stack. It’s an excellent choline source. It’ll increase your brain energy levels by boosting oxygen flow. It helps flush out dangerous free radicals and cellular waste. And will help improve memory and cognition.
Centrophenoxine vs. DMAE: What’s the Difference?
DMAE is used to make Centrophenoxine. DMAE is found in small amounts in your brain. A good food source of DMAE is fish.But there is little evidence that DMAE as a supplement actually crosses the blood-brain barrier. And if it provides the brain enough cholineneeded to make acetylcholine.
Centrophenoxine seems to solve the blood-brain barrier problem. Adding pCPA to DMAE helps DMAE enter your brain. And this combination also seems to be an effective way to boost acetylcholine.
If you’re considering adding DMAE to your stack, Centrophenoxine may be a better alternative.
How does Centrophenoxine Work in the Brain?
Centrophenoxine boosts brain health and function in several ways. But two in particular stand out.
1. Centrophenoxine helps improve memory by boosting Acetylcholine (ACh) in your brain.
Researchers set out to prove this in a clinical trial using lab rats. In this study they compared Centrophenoxine with DMAE. And determined that DMAE was about half as potent as Centrophenoxine in boosting choline and ACh levels.
Increased acetylcholine activity helps short-term memory, concentration, and learning.
Removes toxins and cellular trash
2. Lipofuscin are more commonly known as age pigments.They show up as “age spots” or “liver spots” on aging skin. And they hide in cells throughout your body. Including your brain, liver, kidneys, heart, adrenals and nerve cells.
Lipofuscin are the product of oxidation of unsaturated fatty acids. They also contain other cellular heavy metal waste like mercury and aluminum.
The buildup of this toxic mess is caused by a breakdown of your normal cellular waste disposal function. Centrophenoxine helps remove lipofuscin from brain cells. And from cells throughout your body.
The beneficial effects of Centrophenoxine were observed in several lab studies on older animals. Administration to these animals significantly increased life-span, and it boosted learning ability compared to age-matched controls
How Things Go Bad:
As we get older, our brain chemistry and energy metabolism changes.
↓ Brain cell membranes degenerate from toxic buildup
↓ Memory, recall, reaction time and mood diminish
↓ Acetylcholine levels decline
All of these age-related changes are contributing factors to the neurodegenerative diseases of aging. Including Alzheimer’s and dementia.
But even if you’re not concerned with anti-aging, Centrophenoxine can help.
Centrophenoxine to the Rescue
Centrophenoxine is one of the oldest and most studied nootropics available today. It was developed in France in 1959. Primarily in the search for something to combat age-related cognitive decline.
Centrophenoxine is a combination of pCPA and DMAE. Experience has shown that DMAE can boost acetylcholine levels in the brain. But there’s very little evidence that it can cross the blood-brain barrier. pCPAseems to solve that transport problem.
Centrophenoxine is water-soluble and quickly enters your brain after you take it. Once in your brain, it boosts signal transmission, and protects neurons.
Centrophenoxine gets to work right away boosting Acetylcholine. And it gets busy clearing cells of free radicals and Lipofuscin.
How does Centrophenoxine feel?
Centrophenoxine offers a gentle brain energy boost when you take it first thing in the morning. You’re able to remember things a little easier. Recall when you need it seems effortless.
Centrophenoxine works particularly well stacked with Aniracetam, Noopept, and Piracetam. It provides some of the extra acetylcholine Racetams demand when you take them.
And if you dose half in the morning, and the other half early afternoon, you should feel a brain energy boost throughout your day.
Centrophenoxine Relieves the Symptoms of ADHD
A prescription form of DMAE called Deanol was used in the 1960’s and 70’s to treat learning and behavioral problems in children. What’s now known as ADHD.
A 3-month, double-blind, placebo-controlled trial involving 74 children was conducted in 1975. They were split into groups and given 40 mg. of Ritalin or 500 mg of Deanol (DMAE). Positive results from this trial showed DMAE comparable to Ritalin in effectiveness in controlling ADHD.
Centrophenoxine is Anti-Aging
Centrophenoxine is not only an effective cognition booster, it helps reverse the effects of aging in your brain. Much of brain cell membrane is made of phospholipids (fat). And it oxidizes as we age. In other words, free radicals build up. And are not removed from cells efficiently the older we get.
Aging brain cells also get clogged up with lipofuscin. Lipofuscin are the product of oxidation of unsaturated fatty acids. They also contain other cellular heavy metal waste like mercury and aluminum. You see lipofuscin show up as ‘age spots’ on older skin. The same thing happens in your brain.
Studies have shown that Centrophenoxine helps ‘flush out’ free radicals and lipofuscin from brain cells.And used by younger neurohackers, helps this cellular waste from building up in the first place.
Researchers in Hungary conducted a double-blind clinical trial with 50 people suffering from dementia. Average age was 77 years. They gave one group 2 grams of Centrophenoxine for 8 weeks.
They found that Centrophenoxine rehydrated ‘intracellular mass’. Proving this compound as a powerful free radical scavenger. It removed free radicals from aging brain cells. And restored them to a healthy state.
In another study in India, researchers worked with male Wistar rats aged 4, 8, 16 and 24 months. They used these ages because they correlate with human aging from young to elderly.
Just like in humans, lipid oxidation and lipofuscin concentration increased with age. The experiment also showed that cellular free radical damage and lipofuscin buildup happened at the same time.
This buildup of cellular waste contributes to age-related decline in neuronal electrical activity (neural signaling). Cognition, memory and learning are all affected. The research team found that Centrophenoxine had no effect on younger rat brains. But in the two older age groups they saw a significant decrease in lipid oxidation and lipofuscin concentration.
Showing conclusively the anti-aging action of Centrophenoxine.
Centrophenoxine Improves Memory
Centrophenoxine boosts neuronal glucose and oxygen uptake in the brain. And helps the production of RNA and protein. RNA is derived from DNA in the cell nucleus. And enable neurons to form proteins. Which help encode memory and repair damage to brain cells.
In one double-blind clinical trial, researchers worked with 50 people suffering from ‘dementias of medium level’. They gave the group 2 grams of Centrophenoxine, or a placebo for 8 weeks. 48% of the group that received Centrophenoxine showed improvements in memory.
Another study was made of the effects of Centrophenoxine on the learning and memory of old mice. One group of mice were treated for 3 months and the other group received a placebo. The treated animals showed a significant improvement in memory and learning.
Centrophenoxine comes in powder form and capsules. Capsules are typically 250 – 400 mg.
Centrophenoxine is water-soluble so it’s not necessary to take it with a fat or oil. You may find it absorbs better or more quickly when taken with food.