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Deprenyl is an anti-depressant drug that was discovered in Hungary more than 30 years ago. Since that time, it has undergone a number of clinical studies and has been widely prescribed for several different medical purposes.
Deprenyl is an MAO-B inhibitor and is sometimes used for off-label purposes as a Dopaminergic Nootropic supplement. As a drug, during the 1990’s this actually became the standard treatment for Parkinson’s Disease after it was shown to be more effective than L-Dopa treatments.
There is a lot of evidence suggesting that L-Deprenyl (Selegiline, Anipryl, Eldepryl) may possess significant anti-aging and neuro-protective properties. Deprenyl belongs to a class of medications known as Phenethylamines. Technically speaking, it is a derivative of levomethamphetamine with a propargyl group attached to its nitrogen atom.
This also is partly responsible for the drug being considered as an MAO-B inhibitor. As such it is primarily responsible for helping to regulate levels of Dopamine within the brain.
Dopamine is important both for supporting a positive mood and for cognitive functions related to attention, planning and inhibition control. Using Deprenyl can provide a number of Nootropic benefits, but you need a prescription to use it in the USA.
Although all of the specific mechanisms and methods of action for Deprenyl are not fully understood there are some clues.
For one thing, this drug helps to increase several neural growth factors. These include superoxide dismutase (SOD) and catalase. Glutathione is also enhanced.
It also works by metabolizing into Methamphetamine. Interestingly enough, despite this conversion, it is not regarded as being psychoactive and it does not create or lead to addiction of any type.
This drug is one of the few (possibly the only) chemicals known to actually stimulate the substantia nigra which is a tiny area of the brain exceptionally rich in Dopamine neurons. It should also be noted that deficiencies in this powerful neurotransmitter can result in depression or in more serious cases Parkinson’s Diesease and related symptoms.
Dopamine plays a critical role in how we age; the older people are, the lower their levels of Dopamine (generally speaking). When Dopamine levels decline to around 30% of youthful levels, Parkinson’s Disease results. At 10% levels, death is likely.
The major benefit of Deprenyl which has been studied for a long time is the potential to extend life.
Studies and research have determined this drug to activate a pathway known as Nrf2, which is now considered to be a biological route to longevity.
The exciting thing about this is the fact most other routes to supposedly life extension benefits work through an insulin pathway that involves restricting calories. In this case, caloric restriction would not be required.
An interesting side effect is that many people who begun taking this drug for its life extension benefits end up with noticeable increases in their mood and energy. This can lead to greater productivity, more ideas, and enhanced enthusiasm. Because Deprenyl helps to increase and stabilize dopamine activity in the brain, it has a highly anti-depressant and anti-anxiety effect that can lead to increased motivation, drive and excitement for life.
Deprenyl has been used as an off-label ADHD treatment since dopamine is also involved in so-called executive brain functions related to attention, concentration and inhibition control.
Deprenyl also acts as a neuro-protective substance which means it can improve the underlying health of your neurons and other brain cells. It can protect nerve cells from various toxins as well as rescuing or healing (at least to some degree) already damaged nerve cells. It has not been determined if these benefits are due to the drug acting as an anti-oxidant or some other property.
There are additional benefits which some users report such as the potential for increasing male libido. However, this is normally only associated with men over 50. Deprenyl has also been found to help increase cognition and memory in Alzheimer’s patients.
Those suffering from Parkinson’s Disease have generally noticed a slowing in the progression of their disease. According to early research, the drug is actually able to delay the time at which the standard treatment for these degenerative diseases becomes required.
As far as the recommended dosage for Deprenyl, goes most people are advised to start and with a very low dosage. Although studies have tested all types of dosages, it should be noted that these were primarily animal studies and levels are really only extrapolated on a human basis. The original developer of this drug actually gave it to his mother, at a dosage of only 5 mg per day; he reported it to have excellent life-extension benefits.
Others have used much higher dosages, with a variety of results. The best advice is to start off with the lowest possible effective dose, typically around 5 mg. Only after you have become familiar with the benefits and effects should you consider increasing the dose.
Remember that this is still a stimulant and it does convert into methamphetamine in your system. For the best advice, speak to a medical professional before using Deprenyl and only take it under the supervision of a doctor.