This page is under construction and subject to change
Desmopressin is a drug also sold and/or distributed under the names DDAVP, DesmoMelt, Stimate, and Minrin.
It is considered to be a synthetic replacement for one of the natural peptides found in the brain – Vasopressin.
Desmopressin is normally used to treat medical conditions such as frequent night time urination and to control increased thirst and loss of water that is associated with diabetes Insipidus (or water diabetes). It may be taken as a tablet/pill, an injection, or a nasal spray medication.
The compound does also have some notable off-label Nootropic benefits, such as improved short-term memory, faster reaction times, and more accurate imprinting of information. These uses for the drug have not been extensively tested and are not recommended for the public at this time.
Some Nootropic users will take Desmopressin without a prescription because it can produce significant gains in memory and information retention. However, this usage may lead to negative side effects and the drug has not been approved as a cognitive enhancement product.
As a Nootropic, Desmopressin is reported to produce an almost eidetic memory for several hours after taking it.
A 1997 study found that after taking a spray of Desmopressin, adolescents saw improved concrete memory of words as well as faster reaction time in a test that involved scanning memorized digits.
Other studies have found it to improve memory task scores of implicational sentences, enhance memory storage and boost memory retrieval.
The exact mechanism of action for this effect is unknown and current research only makes conjecture about how Desmopressin actually affects the central nervous system.
For these reasons, it is not recommended to use Desmopressin as a nootropic and you should not be taking it unless you have been prescribed this drug by a health care professional. There are many other memory-boosting Nootropics for which you do not need a prescription and whose mechanisms of action are fully understood.
From a medical standpoint, Desmopressin is known as the anti-diuretic hormone (ADH). This is primarily due to its effects on the kidneys, which cause them to pass out less water in your urine. This ultimately means that your urine becomes much more concentrated.
In practical terms this can also mean that one will have to go to the bathroom many more times than would be considered normal, since the body still needs to excrete the same amount of water, albeit in much smaller batches.
The mechanisms of action for this main effect is created by the supplement binding to the V2 receptors in the renal collecting ducts. This serves to increase their water reabsorption. It also stimulates the release of von Willebrand Fator from the endothelial cells by acting on this V2 receptor. It also requires less frequent administration since it degrades more slowly than other similar substances.
There are a number of benefits associated with Desmopressin. The supplement is prescribed quite often by doctors for the treatment of nocturnal enuresis. This is a fancy way of saying bed wetting. Of course, the patient must normally be considered otherwise healthy.
Nevertheless, this is considered an effective solution for children; it helps their bodies to make less urine during the night. Using this supplement makes kids more than 4 times as likely to sleep through the night uneventfully as placebo.
Another interesting benefit of this supplement is the treatment of blood clotting disorders. It has been successfully used to promote the release of von Willebrand factor in patients having this disease which prevents proper blood clotting and coagulation. This is also thought to be an effective treatment for those having mild hemophilia and thrombocytopenia. It may also be used with uremic induced platelet dysfunction.
Desmopressin helps to treat the condition known as diabetes insipidus. This is a condition where your body is not able to control the balance of water. Essentially, the kidneys are not able to regulate how much water passes out in your urine as well as normal.
What this supplement does in such a situation is to replace the ADH that the body is lacking. This has an effect almost equal to what normal kidneys would—it helps to control the amount of urine that you pass.
There have been a number of internet reports of this supplement acting in a Nootropic fashion and having some cognitive enhancing or memory boosting effects. Some people have reported purchasing the drug illegally online from international vendors and then taking it as a study drug before exams.
Although it may improve memory for some people in isolated circumstances, not enough is understood about the effects of this drug and there are some very serious negative side effects that can occur if it is misused. Only take Desmopressin for its recommended uses.
There are a number of side effects which have been associated with this drug. One of the things that it actually does is to reduce the amount of sodium and electrolytes in your blood.
This may, therefore, lead to a number of possible effects like chills, confusion, convulsions or seizures, decreased urination, drowsiness, fast heartbeat, fever, a continuous or returning headache, shortness of breath or wheezing, tightness in the chest, skin rash, itching, or rapid weight gain.
Generally, if any of these occur you need to call your doctor or other qualified medical professional immediately.
Since there are a number of different (although related) uses of this medication, there will be a number of different recommended dosage ranges. Factors can include things like the strength of the medication, how many doses used each day, time between doses, and even the length of time you will be using.
As an example, using this supplement to control water diabetes expect an initial dose of .05 mg twice a day. Later, this could be changed to a range of 0.1 to 0.8 mg per day, possibly divided into several administrations. Of course, dosage for children should be determined by a qualified medical professional.