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Hydergine is also known as Ergoloid Mesylates, co-dergocrine mesilate, or Dihydroergotoxine Mesylate.
This supplement, created in the 1940’s, is derived from rye and has become one of the world’s most useful and popular ‘smart drugs’ or cognitive enhancers.
Hydergine was actually created by Albert Hofman who also discovered LSD, while working for the Sandoz pharmaceutical company in Switzerland. It is currently being used for treating age-related cognitive decline, memory enhancement, and as a powerful anti-oxidant.
Hydergine also improves blood and oxygen flow to the brain via ganglion cell metabolism and it is a powerful anti-oxidant for brain tissue. Hydergine physical benefits include regulation of blood pressure. It delivers cognitive benefits of improved mental clarity, better attention span, and alleviation of some depression symptoms.
It may even have benefits for stroke recovery and has been approved by the FDA for the treatment of senility and cerebrovascular insufficiency.
Despite the facts that this drug has been around for decades (almost 80 years, in fact) and is one of the most researched of all the cognitive enhancers on the market, the exact mechanisms of action still remain somewhat mysterious.
What is generally accepted is that this supplement affects a number of different neurotransmitters along with the brain’s energy utilization systems.
Research indicates that Hydergine interacts directly with subtypes of Alpha-Adrenoceptors, Dopamine, and Serotonin receptors. This serves to facilitate the release of Dopamine, Norepinephrine, and Acetylcholine (all powerful brain chemicals in their own right).
It is generally accepted that the effects upon these individual chemicals and systems directly lead to Hydergine’s main benefits.
Another effect is that of helping to increase levels of blood flow to the brain. The supplement also improves oxygen utilization in the brain by enhancing metabolism of the ganglion cells. Overall, it is thought that these effects may offer a slight boost to all cognitive functions.
One of the most impressive benefits of Hydergine is the ability to help with stroke recovery.
If the caught in time, this supplement can even be administered prior to surgery or treatment as a method of delaying some of the damaging effects.
It has also been shown to improve the speed and magnitude of post-operative recovery as well.
Hydergine has significant benefits upon blood pressure and oxygen levels in the brain. It helps to normalize systolic blood pressure along with reducing very high cholesterol levels. There is also evidence suggesting it can decrease feelings of lethargy and optimize the amount of oxygen uptake to the brain.
Due its multitude of effects and modulations on different neurotransmitters, there are also a number of cognitive benefits associated with this supplement. Many users report a significant increase in their level of memory as well as an increased learning capacity.
Another potential benefit that is common to many Nootropics is an improvement in mental clarity and an end to so-called ‘brain fog.’ This also tends to promote an enhanced attention span and improved focus and concentration. Some users reviews report that this supplement helps to improve symptoms of mild depression.
Researchers continue to explore the possibilities of using Hydergine as a treatment for age-related cognitive decline, under the theory of this supplement acting as a neuro-protective.
This supplement is generally considered to be very safe and most people do not encounter side effects. However, always remember that this is a powerful cognitive enhancer that can increase levels of certain neurotransmitters in your brain.
It is important to follow the recommended usage guidelines properly and take precautions to ensure that you do not experience any negative outcomes.
Serious Hydergine side effects are quite rare but approximately 3% of people in studies do experience some mild side effects including nausea, anorexia, vomiting, abdominal pain, dizziness, headaches, and sleep disorders.
The recommended dosage of Hydergine is dependent on a lot of different factors and there is still quite a bit of disagreement about how much should be administered.
For example, in the USA, a common Hydergine dosage is generally considered to be 1 mg, taken up to three times daily. In many other countries throughout Europe and also in Japan and in the United Kingdom, medical professionals regularly administer up to 12 mg of this supplement per day, all without any serious side effects.
There are a number of researchers who still contend that this recommended dose is way too low. This, they say, is an explanation for why a number of studies display lackluster results. They argue Hyderdine powder could help more people, especially those with diseases like Alzheimer’s, if the dosage was increased.