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Memantine is a prescription medication used to treat elderly patients with Alzheimers or dementia. It has also recently gained hype as a very clean, safe substance to use when suffering from drug dependence and tolerance. This drug is an NMDA receptor antagonist, which places it in the same category as many other drugs (including cough syrup, Magnesium, and Ketamine.)
Memantine is a strong anxiolytic compound, and is known to increases focus and memory. Also, some have reported Memantine as a remedy to the negative sexual side effects of SSRI's.
This is a class of drug that many people are very excited about because of its neurological properties – namely the halting and even potential reversal of tolerance to amphetamines and opiates. The implications are huge. The NMDA receptor is essentially a channel that allows for electrical signals to pass through neurons in your brain. In order for the electricity to flow properly the channel needs to be open. In order for the channel to be open, there needs to be glutamate and glycine bound to the receptor – we refer to the open channel as being activated. If, however, there is something prohibiting this process then the channel remains closed. Memantine falls into one of the categories of antagonists known as “uncompetitive,” which means that it actually goes in and obstructs the open channel so nothing can pass through.
When Amphetamines are used, or any other kind of excitatory factor – there is an influx of calcium ions through the above-mentioned channel. This influx, or movement, of Ca ions tells your body that their receptors are being overused. Our body needs to regulate itself and adjust appropriately, leaving the drug user with less ability to induce an excited state in their brain. In the future when taking the same drug, our body will already be pre-disposed to that unnatural stimulation and be quicker to adjust. The Memantine stops this influx of Ca ions which inhibits the body from becoming aware that it is being overstimulated – hence, tolerance is halted and diminished.
Memantine is used commonly, and with great success, in treating Amphetamine tolerance.
It is recommended to start with 5 mg every other day for 7 days and see how you feel. Then try 10 mg every other day for a week. After that you can move up to 10 mg a day for a week. By then you should have a good ideas how it will affect you.
As with many other Nootropics, it wouldn't be a bad idea to cycle this Nootropic. That is, take days off every now and then.