N-phenylacetyl-L-Prolylglycine ethyl ester, or brand name “Noopept,” is a highly potent synthetic Nootropic, perhaps the most powerful one available. Noopept greatly enhances creativity, imagination, memory, focus and other cognitive functions. This peptide Nootropic is said to have neuroprotective, psychostimulatory, and anxiolytic effects in your brain. It also promotes overall cognitive health and memory. In other words, it does everything you’d want a Nootropic to do. However, because of its potency, extra precautions should be taken.
Although Noopept is not a Racetam, it does inhibit production of Acetylcholine. Because of this, a larger dose can lead to headaches as a Racetam would. Choline supplements should be taken with Noopept to counter the effects of Acetylcholine inhibition. When used in a responsible manner, Noopept is an excellent creativity and imagination enhancer.
Mental energy is also improved. Many describe using Noopept as clearing brain fog. Everything will become more clear and require less thought when supplementing with Noopept. Attention span is improved along with greater concentration and focus. In this regard many users also are able to see significant improvements in their levels of stress and anxiety.
Different people will experience these effects in different ways. Some may find them to be subtle improvements, such as being able to hold conversations longer and with much less effort (and then remember every detail later). Others may see some significant improvements when taking Noopept and are subsequently able to remember almost everything. The same goes for enhanced learning capacity.
Noopept is considered a neuroprotectant, meaning that it has the ability to help protect the neurons in the brain from damage. Much as an antioxidant is able to rid the body (or brain) of toxins and poisons, so can Noopept. Stress caused by oxidation is reduced, and many researchers also think that damage from excessive alcohol consumption may also be reduced. Overall brain communication is also improved.
The development of connections and growth of new synapses that connect the left and right hemispheres of the brain are greatly facilitated while taking Noopept. This allows for some interesting and unique integrations between functions and abilities normally associated with particular side of the brain. It is also this integration process which many researchers have postulated as the main reason for long-term memory improvement as well as the anti-anxiety benefits promoted with this amazing substance.
Noopept (N-Phenylacetyl-L-Prolylglycine Ethyl Ester or GVS-111)is often included in the Racetam-family of Nootropic compounds. But is not a true “Racetam” because it does not have a 2-oxo-pyrrolidine nucleus.
Noopept was developed in Russia where it is called Ноопепт or GVS-111. Russian-based pharmaceutical company JSC LEKKO Pharmaceuticals synthesized Noopept in 1996 based off the endogenous neuropeptide cycloprolylglycine (CPG).
Researchers in Moscow found Noopept similar to Piracetam in not only it’s Nootropic effect, but also anxiolytic activity.
Noopept is a water-soluble Ampakine Nootropic. AMPA (O-Amino-3-Hydroxy-5-Methyl-4-Isoxazolepropionic) refers to one of three glutamate receptors in your brain.
Noopept could also be considered a Cholinergic compound because it affects acetylcholine levels in the brain.
One of the newer synthetic Nootropic compounds, Noopept is known as a cognitive enhancer. And is known for its anxiolytic, or anti-anxiety effects.
Noopept is considered to be up to 1000-times more potent than Piracetam. As an ampakine Nootropic, it helps increase attention span, alertness and boosts all three levels of memory. Memory formation, retention and recall.
Ampakines tend to have a stimulant effect. But do not produce the same stimulant side effects as Ritalin or coffee from prolonged use.
Noopept vs. Piracetam: What’s the Difference?
Russian-based pharmaceutical company JSC LEKKO Pharmaceuticalsdeveloped Noopept in the late 1996 as a peptide analogue of the original Nootropic Piracetam.
Noopept and Piracetam are both water-soluble. And both Noopept and Piracetam are cognitive enhancers. Both have neuroprotective and anxiolytic(anti-anxiety) qualities. Both Racetams are able to improve learning and memory. And both are able to repair brain damage.
But Noopept has additional benefits not shared with Piracetam. First, the effective dose of Noopept compared to Piracetam is 1,000-times lower. A typical dose of Noopept is 10 – 30 mg while Piracetam is often dosed up to 3 or 4,000 mg.
Second, Piracetam facilitates only the early stages of the memory process. On the other hand, Noopept influences memory consolidationAND retrieval steps as well. So Noopept helps you develop the memory, retain the memory, and then recall what you have stored in memory
Noopept also has additional selective anxiolytic (anti-anxiety) action.Researchers believe this is due in part to Noopept’s antioxidant effect, anti-inflammatory action, and the ability to prevent the neurotoxic effect of too much calcium and glutamate.
How does Noopept work in the Brain?
Noopept boosts brain health and function in several ways. But two in particular stand out.
Moduleates Acetylcholine (Brain Health)
1. Noopept modulates AMPA and NMDA receptors Andacetylcholine (ACh) transmission. Noopept boosts the level of Cycloprolylglycine (CPG) in the brain. CPG is a Dipeptide consisting of Proline and Glycine which acts as a modulator of Acetylcholine transmission, and AMPA and NMDA receptors.
When brain cells are starved of oxygen, glutamate which is your brain’s primary excitatory neurotransmitter, does not work efficiently with neuroreceptors. The result can be a toxic buildup of glutamate within brain cells. Causing neuron damage and ultimately, neuron death.
Noopept modulates neuroreceptor function keeping glutamate transmission at normal levels. Protecting neurons and other brain cells from glutamate damage.
Noopept has also been shown to modulate acetylcholine flow in your brain. Restoring the harmony of glutamate and acetylcholine function not only protects your brain from damage. It can boost cognition, memory, learning, recall, mood and relieve anxiety.
Neuroprotectant, and neuroplasticity promoter
2. Noopept increases Nerve Growth Factor (NGF), Brain-Derived Neurotrophic Factor (BDNF) and mRNA. NGF and BDNF are directly related to neuroplasticity. This ability to repair and even grow new brain cells can have profound implications. Particularly with someone with neurodegenerative brain damage like Parkinson’s or Alzheimer’s. And even affecting Long-Term Potentiation needed for long-term memory development.
mRNA affects the expression of genes and intracellular communication in brain cells. This ongoing brain signaling and gene expression within brain cells is required for healthy cognition.
One study conducted in Moscow showed long-term use of Noopept boosted NGF, BDNF and mRNA. The animal subjects in this study showed no sign of tolerance. And long-term use of Noopept even potentiated the neurotrophic effect.
How things go bad
Glutamate is an excitatory relative of GABA. While GABA has a calming effect, glutamate stimulates. Glutamate is the most common neurotransmitter in the central nervous system.
But Glutamate can be toxic to neurons. And too much of it in your brain can kill brain cells. Lou Gehrig’s Disease for example, is caused by excess glutamate.
But Glutamate is a pivotal neurotransmitter in the brain. It links the brain circuits involved in memory, learning and perception.
↑ Too much glutamate can kill neurons
↓ Too little glutamate can cause problems with memory, learning and perception
↓ Acetylcholine levels decline
↓ Nerve Growth Factor declines
↓ Brain-Derived Neurotrophic Factor declines
All of these changes can happen at any age. And are a product of the food we eat, what we drink, lifestyle habits, the air we breathe and more.
So Noopept can help for age-related cognitive decline, as well as a student looking to do better in school. By boosting NGF, BDNF and Acetylcholine, and controlling Glutamate in the brain.
Noopept to the rescue
Noopept modulates AMPA and NDMA receptors. AMPA receptors are associated with how glutamate and calcium is used in your brain. With Noopept, it’s more of a neuroprotective role.
Similar to the AMPA receptor, the NMDA receptor is also associated with glutamate and calcium use in your brain. They work together to modulate how neurons use glutamate.
Noopept modulates levels of glutamate within and between neurons. It prevents glutamate toxicity, and influences Long-Term Potentiation (LTP). LTP is associated with neuroplasticity that allows long-term memories to form.
There is clinical evidence that Noopept boosts communication and neuron signaling. By boosting Alpha and Beta brain wave activity. You become calmer and more creative. It’s easier to go into a flow state. And you are prone to making innovative and resourceful decisions.
Noopept produces an anxiolytic (anti-anxiety) effect. It stimulates Dopamine receptors (D2 and D3) and Acetylcholine Nicotinic receptors. And Noopept also seems to modulate some Serotonin receptors. All contributing to a better mood and less anxiety.
Noopept has been shown in the lab to boost Nerve Growth Factor (NGF)and Brain-Derived Neurotrophic Factor (BDNF). NGF and BDNF are both involved in neuroplasticity, and the repair and replacement of damaged brain cells. Resulting in overall better brain health, memory and cognition.
Noopept is water-soluble and quickly enters your brain after you take it. Once in your brain, it boosts signal transmission, and protects neurons.
How does Noopept feel?
Nootropics users report:
Noopept as a study aid
* On its own, Noopept increases focus and attention for many neurohackers. Mental arithmetic and grasping difficult concepts is easier.
Increased verbal fluidity
* Your conversation skills could increase with Noopept. Vocabulary comes easier. Being able to focus contributes to a more balanced dialogue. Neurohackers report being more outgoing, friendly and less self-conscious.
* With Noopept you may find yourself better able to deal with stressful situations and work issues that normally get you down. Once you get past the first few weeks of unpleasant memories related to PTSD you may find overwhelming emotions will subside. You could feel detached in a pleasant way from painful memories.
* Many users report increased pleasure when listening to music while using Noopept. For some it takes music do a different plane. Distinguishing between instruments in sound tracks is easier. As a whole, music sounds better.
* Noopept affects NGF and BDNF which affects long-term potentiation. Some neurohackers report memories long forgotten suddenly spring up. Which could be good or bad I suppose depending on the memory. But reports say memories are clear. And if they’re unpleasant there is an emotional detachment shielding from unpleasant feelings.
You should be able to experience the effects of Noopept soon after you take it. It’s water-soluble and enters your cells quickly especially if you take it sublingually.
A word of caution however; don’t go over the recommended 10 – 30 mg per day dose! You will not experience any added benefit, and could bring on unwanted side effects.
There is some debate on the water-solubility of Noopept. It’s not truly fat-soluble but it certainly doesn’t hurt to use a quality “good fat” when taking your Noopept dose.
A study published by the Russian Academy of Medical Sciences in Moscow shows that Noopept stimulates Nerve Growth Factor (NGF) and Brain-Derived Neurotrophic Factor (BDNF).
In this study, researchers studied the effect of single and long-term treatment (28 days) of Noopept. They found that one-time treatment boosted mRNA in the cerebral cortex of rats. mRNA is a molecule in brain cells that carries codes from DNA where they specify the amino acid sequence of proteins.
Improving Neurotrophin synthesis in the hippocampus boosts cognitive function. Particularly consolidation and delayed memory retrieval.
Researchers in Moscow studied the effects of injecting Noopept in rats to see how it would affect brain waves.
Noopept is known within the Nootropic community for enhancing memory. And dozens of studies support this claim of better memory when using Noopept.
One study done at the Russian Academy of Medical Sciences in Moscow experimented with Noopept on rats. The animals were trained in passive avoidance response.
The animal’s ability to both form a memory and retain a memory was impaired. But once the rats received a dose of Noopept, they were able to retain a memory and retrieve that memory later.
In other words, Noopept normalized learning capacity in animals with damage done to their cerebral cortex. And promoted training ability in rats with a hereditary learning deficit.
Another study, again done with rats noted that Noopept stimulated learning after just a single administration. And repeated administration actually increased the number of successful learners among the animals who failed the initial training.
Noopept is sold in tablet, capsule and powder form. Tablets and capsules are usually 10 mg each.
In Russia and some other Eastern European countries, Noopept is a prescription drug.