Phenylpiracetam (Phenotropil) is a Racetam drug derived from Piracetam in where the only modification is the addition of a phenyl group to its structure. It appears to require much lower doses for similar properties, and appears to have psycho-stimulatory effects.
Phenylpiracetam is reported to be more neuroprotective than Piracetam is, but also possesses psychostimulatory properties and is reported to enhance physical performance.
There is a fair bit of research to suggest that Phenylpiracetam is effective, like other Racetams, in attenuating the rate of and symptoms of cognitive decline. Many of these studies use Phenylpiracetam for over one month's time, and the benefits seen may only apply to organic causes of cognitive decline (dementia and stroke) rather than traumatic brain injury.
There is one rat study noting cognitive enhancement in otherwise healthy young rats, and this study only noted benefit with the R-isomer (the racemic mixture, which is commonly sold, failed to outperform control). While cognitive enhancing properties of Phenylpiracetam in youth cannot be ruled out, they are possibly distinct from the psycho-stimulatory properties (which occur with said racemic mixture and the R-isomer).
Phenylpiracetam (2-Oxo-4-Phenylpyrrolidin-1-yl-Acetamide) was created by adding a phenyl group to the original Nootropic Piracetam.
Russian chemists synthesized Phenylpiracetam in 1983 to boost the physical and mental performance of astronauts during space flight. It’s currently used by Russian cosmonauts on the International Space Station.
Phenylpiracetam combats physical and mental fatigue. It enhances memory, mood and focus. It facilitates learning and retention, reduces brain fog, increases alertness and boosts physical stamina and tolerance to cold.
Phenylpiracetam is also an effective treatment for epilepsy. This debilitating condition is caused by sudden surges of electrical activity in the brain. This temporary disturbance in messaging systems between brain cells can cause a seizure. Normal brain function gets halted or mixed up. This is where Phenylpiracetam comes in.
Phenylpiracetam has been shown in clinical studies to affect Alpha and Beta brain waves. Scientists haven’t quite figured out why it works, but Phenylpiracetam has an ‘anti-convulsive’ action in the brain. They did conclude after one clinical trial, “Phenotropil reduced the frequency of seizures and improved cognitive function in the absence of epileptiform EEG abnormalities.”
Phenylpiracetam is sold as a prescription drug in Russia and several Eastern European countries. In the United States, Phenylpiracetam is sold as an unregulated OTC research compound.
Phenylpiracetam boosts brain health and function in several ways. But two in particular stand out.
1. Phenylpiracetam increases the density of neuroreceptors. Studies have shown it increases the density of acetylcholine (ACh), Dopamine, GABA, and NMDA receptors. This translates into more receptors for each of these important neurotransmitters to bind with and boosts their effectiveness.
The increase in density of neuroreceptors likely accounts for Phenylpiracetam’s stimulant-like properties. Similar to Ritalin or Adderall, this nootropic increases the effectiveness of dopamine in your brain. Increasing alertness, decision-making capability, and cognition.
But unlike stimulants like Ritalin and Adderall, Phenylpiracetam does not come with any stimulant-like side effects. You should not experience any fatigue, rapid heartbeat, decreased appetite or irritability. Rather you’ll feel increased stamina, have more physical endurance and get smarter.
Just don’t try using Phenylpiracetam if you’re planning on being an Olympic athlete. It was banned several years ago because it’s too effective to be used in professional sports. We don’t want an unfair advantage now, do we?
2. For similar reasons to how Phenylpiracetam works as a stimulant, it can also tame symptoms of anxiety and depression. It increases the density of receptors for acetylcholine (ACh), GABA and NMDA receptors.
This increase in receptor sites for GABA, choline and Glutamate affects levels of the calming neurotransmitters GABA and serotonin in your brain. Phenylpiracetam floods your brain with the neurochemicals you need to chill out.
As we get older, our brain chemistry and metabolism changes. And it seems these changes are affecting younger and younger people.
All of these changes are contributing factors to age-related cognitive decline. Early signs of these effects can be seen in poor decision-making, difficulty learning, and even recalling simple things like an important appointment.
But even if you’re not concerned with the signs of aging, Phenylpiracetam can help.
Phenylpiracetam modulates neuroreceptors. It’s been shown to increase the density of receptors for GABA, NMDA, dopamine and acetylcholine.
More neuroreceptors result in more of each neurotransmitter being able to bind to neurons. And affect alertness, cognition, memory, recall and mood.
Phenylpiracetam has a positive effect on physical performance by increasing endurance, and reducing physical and mental fatigue. In fact, these effects are so potent that Phenylpiracetam has been banned from professional sports by the World Anti-Doping Agency.
Phenylpiracetam has been shown to act as a stimulant. But unlike pharmaceutical drugs, it does not affect your cardiovascular or respiratory system. And does not have the side effects of jitteriness, restlessness or irritability like regular stimulants.
Phenylpiracetam is also noted for increasing your threshold to tolerance for cold.
Many Nootropic folk say Phenylpiracetam is the strongest Nootropic they’ve ever experienced. It’s highly bioavailable and you experience the effects within 30 minutes of taking it.
* Phenylpiracetam increases concentration, motivation, memory, physical endurance, and tolerance to cold. Learning is quicker and stress is reduced.
* Learning and processing information becomes easier with Phenylpiracetam. You’re not re-reading sentences and paragraphs trying to understand them.
* Short and long-term memory improves. Motor skills improve so your typing faster and more accurately.
* Those dealing with depression report a decrease in depressive symptoms. More confidence helps in social situations and conversations are easier.
* Productivity rises and you assume a “get it done’ mentality. Procrastination is a thing of the past with this supplement.
* Phenylpiracetam is a popular pre-workout supplement. It increases your endurance and reduces both physical and mental fatigue. And if you’re one of the unfortunate ones who live in a cold climate you’ll find that your tolerance for cold is better.
Phenylpiracetam was developed in Russia in 1983. And the majority of research done with this nootropic has been conducted in Russia. Published in Russian medical journals in Russian.
So we have limited clinical trial data to draw on. And like many nootropics we rely on Nootropic user reviews. The following is two samples of clinical trials we were able to find that have been translated into English. And published in Western medical databases.
A study done by Russian researchers investigated the effects of Phenylpiracetam on cognition. 99 adults aged 40 – 60 suffering from cognition deficits due to surgery or brain trauma were enrolled in this study.
Volunteers were given 200 mg of Phenylpiracetam daily for 30 days. The researchers found that those using the nootropic showed a significant improvement in motor coordination, higher brain function, memory, attention and counting. And a reduction in both anxiety and depression.
Researchers in Moscow recruited 400 patients suffering from ischemic stroke. This is the most common type of stroke where blood vessels carrying blood to the brain are blocked by a blood clot.
Half of the group received 400 mg of Phenylpiracetam daily for a year. The control group got a placebo.
The research team found that the group who received Phenylpiracetam experienced a significant restoration in cognitive function, and resumed daily activities. Far better than the control group who took a placebo.
Phenylpiracetam is sold in tablet, capsule and powder form. Tablets and capsules are usually 100 mg each.
Phenylpiracetam is taken at a dosage of 100-200mg acutely, and this dose is taken 2-3 times per day (totaling a daily range of 200-600mg).
The lower range seems effective, but the optimal dosage is not yet known.
You can safely boost daily intake of Phenylpiracetam to 400 mg. But be aware that tolerance to the effects of this Nootropic build quickly. So we recommend using Phenylpiracetam only on days when you need the extra cognitive power. Or cycle the use of this Nootropic one week on, and one week off.