Piracetam is the parent compound of the Racetam class of Nootropic supplements. When supplemented, it provides a mild boost to brain function.
Piracetam is the prototype for Racetam supplements, which are a group of synthetic supplements intended to provide a cognitive boost.
Piracetam has a history of being used to treat cognitive impairment. According to a meta-analysis on human studies, Piracetam improves general cognition when supplemented by people in a state of cognitive decline, such as the kind that comes with aging.
Though Piracetam may be a useful supplement for improving longevity, it offers limited benefits for healthy people. Healthy people supplementing Piracetam do experience little to no cognitive benefit. Though Piracetam supplementation in healthy people is understudied, preliminary evidence suggests that Piracetam is most effective for older people.
Piracetam supplementation has also been found to reduce the chances of a breath-holding spell in children. Piracetam enhances cellular membrane fluidity. This mechanism explains why Piracetam is able to improve cognition, most profoundly in elderly people. Piracetam is as effective as aspirin when it comes to preventing blood clotting, which makes it a useful supplemental intervention after cardiovascular trauma.
Piracetam (2-Oxo-1-Pyrrolidine-Acetamide, Nootropil) was the first in the Racetam-family of nootropic compounds. It is a water-soluble ampakine nootropic. AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic) refers to one of three glutamate receptors in your brain.
Developed by a fellow of famous Russian physiologist Ivan Pavlov, Dr. Corneliu Giurgea first synthesized Piracetam at Belgian-based pharmaceutical company UCB Pharma in the 1964.
Since the discovery of Piracetam, dozens of nootropics have been created in the racetam-class of compounds. And all have a pyrrolidone nucleus at their core.
Piracetam is a cyclic derivative of GABA. But oddly enough, it doesn’t affect GABA receptors in the brain. Instead, Piracetam was found to modulate AMPA and NMDA receptors and improve the function of the neurotransmitter acetylcholine (ACh).
AMPA and NMDA receptors along with acetylcholine are associated with learning and memory. And when Piracetam is stacked with a choline supplement its effects are even more pronounced. Researchers have shown in hundreds of clinical studies that Piracetam significantly improves learning and memory.
Piracetam also increases cerebral blood flow. Blood delivers oxygen and glucose needed for cellular metabolism, and helps carry away cellular waste. Critical for the highly optimized brain.
Piracetam is sold as a prescription drug in many countries around the world. In the United States, Piracetam is sold as an unregulatedOTC research compound.
Piracetam boosts brain health and function in several ways. But two in particular stand out.
1. Through increasing AMPA and NMDA receptors in the brain, it improves the flow of acetylcholine (ACh) and sensitivity and density of ACh receptors.
This German study conducted with lab mice showed Piracetam elevated NMDA receptor density. And normalized the way those receptors worked with L-Glutamate similar to that of a healthy brain.
Deficits at the level of NMDA receptors could be one of the mechanisms of action underlying age-related cognitive decline. And the researchers concluded that Piracetam showed cognition-enhancing properties.
This effect on NMDA receptor sites is directly related to our interest in using Piracetam for Long-Term Potentiation and the support of long-term memory formation.
Neuroplasticity is dependent on activation of NMDA receptors. And this neuroplasticity is at the heart of memory formation. Reviews of Piracetam used by neurohackers frequently report the return of long-lost memories. Further proof of the efficacy in using Piracetam to support learning and memory.
Strokes can be caused by an interruption in cerebral blood flow. Starving parts of the brain of oxygen and glucose. This double-blind, placebo-controlled study was done with 24 stroke patients. One group received 2,400 mg of Piracetam twice daily, and the other a placebo.
Before treatment, both groups were comparable in performance during language tasks. The study found that Piracetam improved recovery of various language functions. And this effect was attributed to increased blood circulation to areas of the brain related to language. The placebo group showed very little improvement in areas of language.
As we get older, our brain chemistry and metabolism changes. And it seems these changes are affecting younger and younger people.
↓ Cerebral blood flow declines
All of these changes are contributing factors to age-related cognitive decline. Early signs of these effects can be seen in poor decision-making, difficulty learning, and even recalling simple things like an important appointment.
But even if you’re not concerned with the signs of aging, Piracetam can help.
Piracetam helps increase blood flow in the brain, improves oxygen levels, enhances glucose use in brain cells, maintains brain cell mitochondria and ATP synthesis.
Piracetam is also a potent modulator of AMPA-sensitive glutamate receptors in neurons. It increases the density of specific binding sites for AMPA in neuronal synapses.
Glutamate is the primary excitatory neurotransmitter in your brain. This glutamate activity by Piracetam affects alertness, focus, attention, memory and learning. And one of the reasons why neurohackers consistently report that Piracetam improves mental performance and memory.
Piracetam increases high-affinity choline uptake (HACU) which is the process that occurs in cholinergic nerve endings and facilitates acetylcholine (ACh) formation. Boosting ACh with Piracetam produces a powerful effect on learning and memory
Piracetam also boosts choline receptor density in the frontal cortex. The area of your brain used for working memory and decision-making.
ATP energy is critical to your brain’s survival. Brain cells must produce all of their own ATP from glucose and oxygen. This brain energy carbohydrate metabolism depends on cerebral blood flow, oxygen uptake and glucose. Piracetam enhances this glucose utilization, and increases ATP synthesis needed to power brain cell mitochondria.
And Piracetam has analgesic (anti-pain) benefits. This anti-pain action is linked to Piracetam’s anti-inflammatory properties.Inflammation can cause pain, and studies have shown Piracetam can have profound effect on pain.
Most report a noticeable benefit from Piracetam after about 2 weeks. Consider that Piracetam is modulating your brain’s chemistry. And this change is unlikely to occur immediately.
Your brain needs some time to adjust to the new change in acetylcholine (ACh) levels and how it uses it. Increased cerebral blood flow takes a while to bring up levels of oxygen and nutrients. And for your neuronal cells to respond. Your mileage may vary depending on your own neuro-chemical makeup.
Many suggest starting with an ‘attack dose’ for the first 3-days. A 3,000 mg ‘attack dose’ of Piracetam for example to start with theoretically gets more of the supplement into your system right away. So it takes less time to build up before you start feeling the effects.
From there step down to a maintenance dose and vary the quantity until you find your own sweet spot.
We have plenty of evidence that Piracetam improves memory in animals and people who are suffering from many types of cognitive impairment. Keep in mind that most of the scientific research available for Nootropics is done for sick people trying to get well. The return on investment for research at institutions and universities comes from treating diseases. And not from helping ordinary biohackers like us trying to get a competitive advantage at work or in school.
We can however extrapolate the findings from these studies and learn if and how something like Piracetam can help our memory and cognition. Once-in-awhile someone does take the time to conduct such a study on healthy people. Like this one done with normal, healthy volunteers.
Researchers gave this healthy group of participants four 400 mg capsules of Piracetam 3-times per day (1,200 mg total) for 14 days. No effects on memory were observed after 7 days during this experiment. But after 14 days verbal learning had significantly increased.
Researchers in Belgium (where Piracetam originated) conducted an analysis of 19 double-blind, placebo-controlled studies done with patients suffering dementia or cognitive impairment and who took Piracetam.
The results of this meta-analysis demonstrated the difference between people who used Piracetam or used a placebo. The end result of this analysis provided compelling evidence for the usefulness of piracetam in a diverse group of people with cognitive impairment.
Several studies and user reviews have shown that Piracetam dosage makes a difference. And unlike some other nootropics where you start at a lower dose and work your way up, with Piracetam we recommend you start at a higher suggested dose.
This study in Germany with 78 elderly patients showed that there was a significant difference in cognition improvement while dosing Piracetam at 1,600 mg 3-times per day. There was no difference in cognition with patients who received 800 mg 3-times per day.
Piracetam is used around the world to treat cognitive impairment in aging, brain injuries, dementia and Alzheimer’s Disease. Several studies show that Piracetam enhances ATP production, mitochondrial membranes and neurite outgrowth in neurons.
In this study, scientists investigated the effects of Piracetam on mitochondrial function. Human brain cells were treated with Piracetam under normal conditions and under conditions imitating aging and damage by ROS (reactive oxygen species). And with cells representing early-stage Alzheimer’s Disease.
The cells representing Alzheimer’s conditions showed impaired mitochondrial function under baseline conditions. Piracetam was able to restore this impairment in cells and shift mitochondrial function back to normal.
The researchers showed that Piracetam is able to repair mitochondria in those with mild Alzheimer’s and return cell function back to normal.
Piracetam is sold in tablet, capsule and powder form. Tablets and capsules are usually 800 mg each.
In Europe, Asia, South America and some other countries around the world, Piracetam is a prescription drug. And sold under many different brand names (including Nootropil).
The standard Piracetam dose for children is between 40-100mg per kilogram of bodyweight. This dose is intended for the treatment of breath-holding spells, though it has also been used for children with dyslexia. The lower end of the range (40-50mg/kg) is used most often.
The standard Piracetam dose for adults is between 1,200-4,800mg a day. The largest effective dose is 1,600mg, taken three times a day for a total of 4,800mg.
You can safely boost daily intake of Piracetam to 9,600 mg if needed. Studies have shown that Piracetam is completely non-toxic even at high doses. You may find however that a lower dose than our recommended amount works better for you.