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Pregnenolone is a steroidal hormone with several powerful nootropic benefits. It is used as a focus booster, mood enhancer and energy pill.
Recent studies have found it effective for improving memory, comprehension, and information processing and critical analysis.
According to Dr. Flood of the Geriatric Research Education and Clinical Center, “Pregnenolone is the most potent memory enhancer yet reported”.
Pregnenolone is also one of the most important hormones within the body, involved in the synthesis of many different types of chemicals and other hormones like Androgens, Estrogens, Glucocorticoids, and more.
This supplement is considered to be a pro-hormone, which essentially means that it leads to the production, development, or synthesis of a number of other chemicals and hormones.
Pregnenolone is synthesized from cholesterol. This occurs primarily in the adrenal glands, but also within the liver, skin, brain, testicles, ovaries, and retinas (eye). As a steroid, this supplement acts as a precursor to DHEA, Progesterone, Testosterone, Estrogen, and Cortisol.
Even though this supplement has some very powerful metabolites, it is also considered to be without significant side effects and very limited anabolic, estrogenic, or androgenic activity.
Pregnenolone and its sulfate (Pregnenolone Sulfate) are excitatory neurosteroids – they stimulate the brain (R).
Pregnenolone is the main steroid produced from cholesterol (R).
Ever since the 1940s, pregnenolone was reported to have anti-stress and mood-elevating effects on factory workers, students, and pilots (R).
Pregnenolone is the main precursor of many other steroid hormones (R). For example, Pregnenolone increases the level of other neurosteroids such as Pregnenolone sulfate and allopregnanolone.
Allopregnanolone is another molecule that increases the growth of neurons, decreases cell death and inflammation (R).
Like most products that can’t be patented, Pregnenolone doesn’t have large clinical trials for various conditions. This is where Selfhacking comes in and testing out if Pregnenolone works for you.
The typical daily dosage range is anywhere between 5 and 20 mg per day. It may even be broken into two equal administrations, one in the morning and the other in the afternoon. Due to the sometimes stimulating effects of this supplement, you may not want to take it too late at night.
While Pregnenolone is one of the safest supplements around, it should still be approached cautiously; begin with the lowest effective dose, most likely 5 mg.